Publication Date
2008
Journal or Book Title
ACS Nano
Abstract
Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding with subsequent condensation. Particles with lysine and lysine dendron functionality formed particularly compact complexes and provided highly efficient gene delivery without any observed cytotoxicity. Nanoparticles functionalized with first generation lysine dendrons (NP−LysG1) were ∼28-fold superior to polylysine in reporter gene expression. These amino acid-based nanoparticles were responsive to intracellular glutathione levels, providing a tool for controlled release and concomitant expression of DNA.
DOI
https://doi.org/10.1021/nn800507t
Pages
2213-2218
Volume
2
Issue
11
Recommended Citation
Ghosh, Partha S.; Kim, Chae-Kyu; Han, Gang; Forbes, Neil S.; and Rotello, Vincent M., "Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles" (2008). ACS Nano. 157.
https://doi.org/10.1021/nn800507t