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The major function of eukaryotic small nucleolar RNAs is nucleotide modification in ribosomal RNA
Abstract
Small nucleolar RNAs (snoRNAs) can be divided into two large families based on conserved sequence elements. These two classes are the box C/D snoRNAs and the box H/ACA snoRNAs. At the onset of this thesis study, a small number of snoRNAs were known to be required for processing (cleavage) of pre-ribosomal RNA; the function of majority of snoRNAs remained an enigma. The thesis research revealed two important and exciting discoveries: (1) the box C/D snoRNAs are mainly involved in guiding the formation of 2$\sp\prime$-O-methylation in rRNA, and; (2) most box HACA snoRNAs direct $\Psi$ modification of rRNA. Taken together, I demonstrated that the main function of the snoRNAs is nucleotide modification of ribosomal RNA.
Subject Area
Molecular biology
Recommended Citation
Ni, Jingwei, "The major function of eukaryotic small nucleolar RNAs is nucleotide modification in ribosomal RNA" (1998). Doctoral Dissertations Available from Proquest. AAI9909197.
https://scholarworks.umass.edu/dissertations/AAI9909197