Floods are a global challenge that is increasing due to changes in climate and human populations. Using an interdisciplinary approach, this work contributes novel methodologies and knowledge to three key challenges associated with floods. The first chapter builds upon the atmospheric and statistical sciences to provide a general methodology for climate informed approaches to projecting long-term flood events based on large-scale ocean-atmospheric processes. The second chapter builds upon the engineering, decision analysis, and economics disciplines to integrate climate-informed projections with decision-scaling, a decision-making under uncertainty framework, to further flood risk management. The third chapter builds upon the social sciences to provide new knowledge on flood risk perception and mitigation in West Africa. The outcomes of this work contribute important advancements to addressing the clear and urgent need for solutions to floods around the world.