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Author ORCID Identifier
https://orcid.org/0000-0001-5665-5098
AccessType
Open Access Dissertation
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Molecular and Cellular Biology
Year Degree Awarded
2020
Month Degree Awarded
February
First Advisor
Daniel Hebert
Second Advisor
Dominique Alfandari
Third Advisor
Peter Chien
Fourth Advisor
Richard Vachet
Subject Categories
Animal Experimentation and Research | Biochemistry | Bioinformatics | Cell and Developmental Biology | Cell Biology | Developmental Biology | Integrative Biology | Molecular Biology | Other Animal Sciences
Abstract
The endoplasmic reticulum (ER) is a complex, multifunctional organelle comprised of a continuous membrane and lumen that is organized into several functional regions. It plays various roles including protein translocation, folding, quality control, secretion, calcium signaling, and lipid biogenesis. Cellular protein homeostasis is maintained by a complicated chaperone network, and the largest functional family within this network consists of proteins containing tetratricopeptide repeats (TPRs). TPRs are well-studied structural motifs that mediate intermolecular protein-protein interactions, supporting interactions with a wide range of ligands or substrates. Nine TPR-containing proteins have been shown to localize to the ER and control protein organization and homeostasis within this multifunctional organelle. Here, we discuss the roles of SEL1L, ERdj6, FICD, TMTC1-4, TTC13 and TTC17 and how they contribute to controlling ER processes and organization. The crucial roles that TPR-containing proteins play in the ER are highlighted by diseases or defects associated with their mutation or disruption.
DOI
https://doi.org/10.7275/3w2g-4r67
Recommended Citation
Bradley-Graham, Jill, "TPR-CONTAINING PROTEINS CONTROL PROTEIN ORGANIZATION AND HOMEOSTASIS FOR THE ENDOPLASMIC RETICULUM" (2020). Doctoral Dissertations. 1814.
https://doi.org/10.7275/3w2g-4r67
https://scholarworks.umass.edu/dissertations_2/1814
Included in
Animal Experimentation and Research Commons, Biochemistry Commons, Bioinformatics Commons, Cell Biology Commons, Developmental Biology Commons, Integrative Biology Commons, Molecular Biology Commons, Other Animal Sciences Commons