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Author ORCID Identifier
N/A
AccessType
Open Access Dissertation
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
Year Degree Awarded
2014
Month Degree Awarded
February
First Advisor
Sankaran Thayumanavan
Subject Categories
Amino Acids, Peptides, and Proteins | Biochemistry | Chemical Actions and Uses | Chemistry | Heterocyclic Compounds | Investigative Techniques | Laboratory and Basic Science Research | Macromolecular Substances | Materials Chemistry | Medicinal and Pharmaceutical Chemistry | Medicinal Chemistry and Pharmaceutics | Medicinal-Pharmaceutical Chemistry | Nanotechnology | Organic Chemicals | Organic Chemistry | Pharmaceutics and Drug Design | Polymer Chemistry
Abstract
Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of encapsulated guest molecules, depending on the initial location of the ligand upon binding to a specific protein; (iii) decorate self-assembling and crosslinkable dendrons aiming to introduce a system incorporating multiple ligands, sequentially responsive to a reducing environment, and to specific proteins.
DOI
https://doi.org/10.7275/3tjw-g174
Recommended Citation
Amado Torres, Diego, "LIGAND-RECEPTOR INTERACTIONS FOR SUPRAMOLECULAR DISASSEMBLY WITH APPLICATIONS IN SCREENING AND DRUG DELIVERY" (2014). Doctoral Dissertations. 49.
https://doi.org/10.7275/3tjw-g174
https://scholarworks.umass.edu/dissertations_2/49
Included in
Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Chemical Actions and Uses Commons, Heterocyclic Compounds Commons, Investigative Techniques Commons, Laboratory and Basic Science Research Commons, Macromolecular Substances Commons, Materials Chemistry Commons, Medicinal and Pharmaceutical Chemistry Commons, Medicinal Chemistry and Pharmaceutics Commons, Medicinal-Pharmaceutical Chemistry Commons, Nanotechnology Commons, Organic Chemicals Commons, Organic Chemistry Commons, Pharmaceutics and Drug Design Commons, Polymer Chemistry Commons