Radiations may trigger protective response within a threshold of doses applied. Exposures above an upper threshold are generally detrimental, while exposures below a lower threshold may or may not increase risks for health. We recently reported that a cellular protective response occurs in interventional cardiologists to counteract the oxidative damage caused by radiation. Here, we demonstrated in an in vitro model represented by whole blood of healthy donors γ-irradiated with 220-440 mGy, that haemolysis of erythrocytes induced by hypochlorous acid was reduced by 40%. The protection triggered by γ- radiations made erythrocytes more resistant to oxidative insult caused by hypochlorous acid which was induced 3 h after irradiation and involved biochemical changes in the syn- thesis and turnover of glutathione. Overall, the biochemical remodelling induced by exposure to γ-radiations might contribute to generate new guidelines in professionally exposed workers.
Tedesco, Idolo; Spagnuolo, Carmela; Russo, Maria; Iannitti, Roberta; Nappo, Annunziata; and Russo, Gian Luigi
"PROTECTIVE EFFECT OF γ-IRRADIATION AGAINST HYPOCHLOROUS ACID- INDUCED HAEMOLYSIS IN HUMAN ERYTHROCYTES,"
Dose-Response: An International Journal:
3, Article 10.
Available at: http://scholarworks.umass.edu/dose_response/vol11/iss3/10