The aim of this paper is to assess the historical role of radiotherapy in the treatment of sinus infections. This assessment involved a literature-based review of how radiotherapy was used to treat sinus infections in the first half of the 20th century. Low doses of x-rays were used with considerable success to treat nearly 3,000 patients of sinus infection in a span of 12 years with these cases being reported in leading medical journals as case stud- ies. The mechanism of x-ray induced reduction of inflammation and increased tissue repair is uncertain but appears to be related to the development of a multifactorial and integrative anti-inflammatory phenotype.
Calabrese, Edward J. and Dhawan, Gaurav
"THE HISTORICAL USE OF RADIOTHERAPY IN THE TREATMENT OF SINUS INFECTIONS,"
Dose-Response: An International Journal:
4, Article 5.
Available at: http://scholarworks.umass.edu/dose_response/vol11/iss4/5