Article Title
Abstract
Whole-body exposure to large radiation doses can cause severe loss of hematopoietic tissue cells and threaten life if the lost cells are not replaced in a timely manner through natural repopulation (a homeostatic mechanism). Repopulation to the baseline level N0 is called reconstitution and a reconstitution deficit (repopulation shortfall) can occur in a dose-related and organ-specific manner. Scott et al. (2013) previously introduced a deterministic version of a threshold exponential (TE) model of tissue-reconstitution deficit at a given follow-up time that was applied to bone marrow and spleen cellularity (number of constituent cells) data obtained 6 weeks after whole-body gamma-ray exposure of female C.B-17 mice. In this paper a more realistic, stochastic version of the TE model is provided that allows radiation response to vary between different individuals. The Stochastic TE model is applied to post gamma-ray-exposure cellularity data previously reported and also to more limited X-ray cellularity data for whole-body irradiated female C.B-17 mice. Results indicate that the population average threshold for a tissue reconstitution deficit appears to be similar for bone marrow and spleen and for 320-kV-spectrum X-rays and Cs- 137 gamma rays. This means that 320-kV spectrum X-rays could successfully be used in conducting such studies.
Recommended Citation
Scott, BR and Potter, CA
(2014)
"STOCHASTIC THRESHOLD EXPONENTIAL (TE) MODEL FOR HEMATOPOIETIC TISSUE RECONSTITUTION DEFICIT AFTER RADIATION DAMAGE,"
Dose-Response: An International Journal: Vol. 12:
Iss.
3, Article 7.
Available at:
https://scholarworks.umass.edu/dose_response/vol12/iss3/7