Effects of low-dose-rate gamma-irradiation on the process of tumorigenesis were investigated in mice treated with a carcinogenic agent or irradiated with high dose X-rays at a high dose rate. A prolonged gamma irradiation at approximately 1 mGy/hr suppressed the appearance of skin tumors induced by methylcholanthrene and delayed the appearance of radiation-induced thymic lymphomas in C57BL/6 mice. We also investigated the effects of low-dose-rate irradiation on disease model mice. In Type II diabetic C57BL/KsJdb/ db (db) mice, the urine glucose level was improved in some of the mice irradiated at 0.70 mGy/hr, but not in non-irradiated control mice. In MRL-lpr/lpr (lpr) mice with severe autoimmune diseases, immunological status was kept better in the mice irradiated at 0.35 or 1.2 mGy/hr. The incidence of a number of symptoms, including lymphadenopathy, splenomegaly and proteinuria, was suppressed by the irradiation. Furthermore, in both of the strains, the low-dose-rate irradiation prolonged the life span of the irradiated mice.
Sakai, Kazuo; Nomura, Takaharu; and Ina, Yasihiro
"ENHANCEMENT OF BIO-PROTECTIVE FUNCTIONS BY LOW DOSE/DOSERATE RADIATION,"
Dose-Response: An International Journal:
4, Article 10.
Available at: http://scholarworks.umass.edu/dose_response/vol4/iss4/10