Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction- induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.
Ji, Li Li; Dickman, Jonathan R; Kang, Chounghun; and Koenig, Ryan
"EXERCISE-INDUCED HORMESIS MAY HELP HEALTHY AGING,"
Dose-Response: An International Journal: Vol. 8
, Article 16.
Available at: http://scholarworks.umass.edu/dose_response/vol8/iss1/16