Human Subjects in Research presents basic ethical issues that face researchers when doing work with human participants. Matt Ronning, Assistant Vice Chancellor for Research Administration Sponsored Programs and Regulatory Compliance, (SPARCS) is our guide for this module. In the Overview section we review chapters from two well known textbooks on Research Ethics. In the Applied Ethics section we focus on the consent form as a contract and comment upon the recurring topics of Justice and Honesty as they apply particularly to human subjects. In the Central Theme section we review institutional guidelines, both at the national and institutional level, utilizing the SPARCS training site. Our Case Study focuses on the graduate student as a research subject. The topic for the Study Question is that of vulnerable populations. We close with the Resource section where you will find a sampling of articles, books and websites.