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Differential Microglial Activation Following Immune Challenge in Peripubertal and Adult Outbred Mice
ORCID
N/A
Access Type
Open Access Thesis
Document Type
thesis
Degree Program
Neuroscience & Behavior
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2015
Month Degree Awarded
May
Abstract
Pubertal development is a time of growth and development in the brain, leading to high sensitivity during this period. Past research in our lab has shown that shipping female inbred and outbred mice during pubertal development alters their sensitivity to steroid hormones in adulthood, thus affecting sexual receptivity, cognition, depression-like behavior, and anxiety-like behavior. Here, we test the hypothesis that mice treated with lipopolysaccharide during pubertal development would have more active microglia, the brain's immune cells, after injection than mice treated with lipopolysaccharide in adulthood. No significant interactions were observed between treatment and age between any brain area measured, suggesting that pubertal development does not render the brain's immune system hypersensitive to environmental stressors.
DOI
https://doi.org/10.7275/7079420
First Advisor
Jeffrey D Blaustein
Recommended Citation
Placzek, David J., "Differential Microglial Activation Following Immune Challenge in Peripubertal and Adult Outbred Mice" (2015). Masters Theses. 254.
https://doi.org/10.7275/7079420
https://scholarworks.umass.edu/masters_theses_2/254
Included in
Animals Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Other Psychiatry and Psychology Commons