Document Type

Open Access Thesis

Embargo Period

5-7-2015

Degree Program

Neuroscience & Behavior

Degree Type

Master of Science (M.S.)

Year Degree Awarded

2015

Month Degree Awarded

May

Advisor Name

Jeffrey

Advisor Middle Initial

D

Advisor Last Name

Blaustein

Abstract

Pubertal development is a time of growth and development in the brain, leading to high sensitivity during this period. Past research in our lab has shown that shipping female inbred and outbred mice during pubertal development alters their sensitivity to steroid hormones in adulthood, thus affecting sexual receptivity, cognition, depression-like behavior, and anxiety-like behavior. Here, we test the hypothesis that mice treated with lipopolysaccharide during pubertal development would have more active microglia, the brain's immune cells, after injection than mice treated with lipopolysaccharide in adulthood. No significant interactions were observed between treatment and age between any brain area measured, suggesting that pubertal development does not render the brain's immune system hypersensitive to environmental stressors.

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