Dissertations from 2009

The Parkin-like ubiquitin E3 ligase Ariadne-1 in the mammalian brain: Potential implications for neurodegenerative disease, Juan G Cadena

The role of EDEM1 in the quality control and degradation of misfolded glycoproteins, James H Cormier

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Delayed anesthetic preconditioning and metallothioneins I+II: Novel mediators of anesthetic-induced protection, Scott David Edmands

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The conformational gymnastics of the Escherichia coli SecA molecular machine and its interactions with signal sequences, Jenny Lynn Maki

WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen, Fei Wang

Dissertations from 2008

Molecular mechanisms through which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interferes with estrogen regulation of PRL gene expression in vivo and in vitro, Jinyan Cao

Regulation of RecA-dependent homologous recombination by 3'-5' exonucleases and the UvrD helicase in Escherichia coli K-12, Richard C Centore

Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy, Ameya S Champhekar

Functional analysis of Moe (Epb4.1l5) in zebrafish development and the identification of novel Epb4.1l5 binding proteins, Arne K Christensen

The role of ovarian hormones in p53-mediated resistance to mammary tumorigenesis, Karen A Dunphy

Drivers performance in response to sight-limited and multi-threat crash scenarios at mid-block crosswalks: An evaluation of advance yield markings and sign prompts, Lisandra Garay-Vega

The roles of signal peptide peptidase-like proteases in Arabidopsis thaliana, Sungwon Han

TRAF-interacting protein, an inhibitor of the canonical nuclear factor-kappaB pathway, plays a key role in the estradiol-dependent apoptosis of the dual-phenotype gamma amino butyric acid/glutamate neurons in the anteroventral periventricular nucleus of the male rat, Sudha Krishnan

A post-import pathway for protein targeting to chloroplast inner membrane, Ming Li

Hormones, growth factors, and the regulation of tumor suppressor pathways involved in parity-induced protection of breast cancer, Lesley Anne Mathews

Novel developmental functions of the Drosophila SOX gene Dichaete, Krishna V Melnattur

Organization and maintenance of the motor nerve terminal: Roles for presynaptic actin and perisynaptic Schwann cells, Stephanie Anne Moeckel Cole

Organization and dynamics of actin and myosin during cytokinesis in mammalian epithelial cells, Kausalya Murthy

The ubiquitin E3 ligase Human Homolog of Drosophila Ariadne-1 (HHARI) is a structural and functional homolog of Parkin and is required for myogenesis, Sangram S Parelkar

Genetic studies of the regulation of RecA activity in Escherichia coli: A two filament model, Nicholas Renzette

Environmental toxicants and white matter composition: Understanding the role of thyroid disruption, David S Sharlin

The study of retinoic acids and Rhodiola as potential chemopreventional and chemotherapeutic reagents of breast cancer, Yifan Tu

Characterization of bendless and interacting partners in Drosophila central synapse formation, Smitha Babu Uthaman

The role of GTP regulation in chloroplast import, Fei Wang

Dissertations from 2007

Energy availability signals and the prohormone convertase 2 gene are regulated by Nhlh2, Dana L Fox

Targeting bacteriolytic therapy of solid tumors with attenuated Salmonella typhimurium, Sabha Ganai

The role of the crumbs complex in vertebrate rod morphogenesis and its regulation by a novel FERM protein mosaic eyes, Ya-Chu Hsu

The role of inositol 1,4,5-trisphosphate receptor type-1 in regulation of intracellular calcium oscillations in mouse eggs, Bora Lee

Changes in the mutual orientation oftRNA and 23SrRNA at the peptidyl transferase center of the ribosome detected by crosslinking of a photoreactive transition-state analog, Anton V Manuilov

Notch functions from the cytoplasm to the nucleus during T cell activation, Hyun Mu Shin

Contribution of non-centrosomal microtubules to mitotic spindle assembly in mammalian cells, Ustun Serdar Tulu

Modulation of Nhlh2 expression by energy availability leads to downstream effects on body weight regulation, Kristen R Vella

Investigations of glycoprotein co-translational maturation in the cell, Ning Wang

Genome-wide analysis for native thyroid hormone targets in developing brain and mechanisms of endocrine disruption at the thyroid hormone receptor, Seo-Hee You

Dissertations from 2006

Functional analysis of Hic-5/ARA55 isoforms in C2C12 myogenesis, Zhengliang Gao

The effects of polychlorinated biphenyls on thyroid hormone-mediated action in vivo and in vitro, Kelly J Gauger

Regulation of p53 by Mdm4 and ovarian hormones in mouse mammary glands, Shaolei Lu

Postsynaptic mechanisms during synaptic plasticity at the Drosophila neuromuscular junction, Dennis Mathew

The building of a centromeric nucleosome: Biochemical analysis and comparison of Cse4p, histone H3 and Cse4-286p to define the unique assembly pathway of a Cse4p nucleosome, Kelcy J Newell

The influence of WC1 isoforms on gammadelta T cell function, Aric N Rogers

The stability of T7 RNA polymerase elongation complexes and promoter function analysis by in vitro selection, Yi Zhou

Dissertations from 2005

The impact of PCBs on thyroid hormone directed brain development in rats, Eric A Iannacone

Molecular and functional analysis of mutations that result in insecticide resistance in Colorado potato beetle, Hyo Jeong Kim

The HFD of Cse4p is sufficient for a functional centromere specific nucleosome: An investigation into kinetochore formation on cen DNA, Lisa M Morey

Microtubule dynamics and behavior during the assembly and disassembly of mammalian mitotic spindles, Nasser M Rusan

Multiple roles for hedgehog signaling in zebrafish pituitary development, Jennifer L Sbrogna

Cloning and functional characterization of the zebrafish mutation belladonna, Anandita Seth

The action of T- and CS-syndrome pyrethroids on voltage-sensitive calcium channels in rat brain, Steven B Symington

EGFR expression and activation in bovine cumulus cells and EGFR intramolecular regulation through interactions between tyrosines, Zhong Zhao

Receptor clusters and dynamics in kinase regulation in bacterial chemotaxis, Li Zhi

Dissertations from 2004

Estrogen and progesterone regulate p53 activity in the mouse mammary epithelium through transforming growth factor beta dependent pathways, Klaus A Becker

Notch-1 regulates IFN-gamma secretion through activation of NF-kappaB, Sridevi Gottipati

NIH 3T3 fibroblast adhesion to a fibronectin substrate: The role of the arachidonic acid signaling pathway, Joffre Angelo Green

Drosophila Wnt-1/Wingless undergoes a hydrophobic modification and is targeted to lipid rafts for secretion, a process that requires Porcupine, Xiaoling Hill

The role of Notch in T cell activation and development, Amy Marie Laws

Dietary phenolics for chemoprevention, Patrick P McCue

Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction, Mary C Packard

Understanding the allosteric mechanism of the Escherichia coli Hsp70 molecular chaperone, DnaK, Renuka Sivendran

Using the mouse egg as a model system for the study of intracellular calcium signaling mechanisms, Jeremy T Smyth

Dissertations from 2003

Cyclooxygenase and cyclic AMP-dependent protein kinase regulate actin organization and cell motility, Honor L Glenn

A new strategy for RNA structure probing in vivo: Targeting methylation small nucleolar RNPs to new sites in ribosomal RNA, Ben Liu

Identification and characterization of cuticular collagens in the human filarial parasite Onchocerca volvulus, Wen Li

Characterization and analysis of the cuticlin gene family of the human parasite Onchocerca volvulus, Michelle Renee Lizotte-Waniewski

The role of N-linked glycans in protein quality control in the early secretory pathway, Sherri L Svedine

When stress is good: Exercise and stress protein responses in mice and humans, Heather Sue Thompson

The role of oxidative stress in apoptosis, Noriko Tonomura

Overlapping and distinct functions for Gli proteins: Key mediators of hedgehog signaling in cell specification during embryonic development, Oksana V Tyurina

Acheron, a novel regulator of myoblast differentiation, Zhaohui Wang

Dissertations from 2002

Studies of the complex of ribosomal protein L1 with its binding site in 23S rRNA: Modification-interference, mutagenesis and crosslinking, Denis Drygin

Diversification of the bovine primary immunoglobulin heavy chain repertoire: Ontological and hypermutational analyses in fetal and neonatal animals, Stephen Mark Jackson

Two new requirements for producing normal ribosomes: (I) A novel helicase is needed for snoRNP biogenesis, and; (II) Pseudoridine modifications in the reaction center are important for ribosome function, Thomas H King

Characterization of arachidonic acid-mediated signal transduction in regulation of NIH-3T3 cell adhesion to extracellular matrix, Rebecca A Stockton

Dissertations from 2001

Structural and functional characterization of the unique N-terminus of Cse4p, A histone H3-like protein at the Saccharomyces cerevisiae centromere, Yinhuai Chen

Cloning and characterization of GUKHolder, a novel synaptically expressed protein that interacts with Discs-Large and SCRIBBLE at the Drosophila neuromuscular junction, L. Sian Gramates

Death associated lepidopteran DALP, and its mammalian ortholog Hic-5, act as negative regulators of muscle differentiation, Yanhui Hu

Structural changes between signaling states of bacterial chemoreceptors probed by solid-state NMR and hydrogen exchange, Owen James Murphy

Biosynthetic introduction of aryl bromide functionality into proteins, Nandita Sharma

Analysis of the interaction between the epidermal growth factor receptor and actin, Jun Tang

Analysis of programmed cell death in Drosophila, John Patrick Wing

Identification of genes affected by fetal alcohol exposure during brain development, Jun Yang

Dissertations from 2000

Maternal thyroid hormone regulates gene expression in the fetal rat brain, Amy Louise Skinner Dowling

The effect of dominant negative EGR-1 and hyperbaric oxygen on immune cell apoptosis, Bishu Jeet Ganguly

Replication and 3'-end repair of a subviral RNA associated with turnip crinkle virus, Hancheng Guan

Inhibition of protein synthesis in Escherichia coli by expression of RNAs containing multiple ribosome binding sites, Mary V Mawn

The localization, differential expression, and potential immunological role of thioredoxin peroxidase-2 (TPX-2) in the filarial parasite Brugia malayi, Lori J Saunders

The role of cell cycle progression and cyclin-dependent kinase 2 in thymocyte negative selection, Jennifer Lynn Trimble

Symptom modulation by subviral RNAs associated with turnip crinkle virus, Jianlong Wang

Towards the isolation of esterase and amidase catalytic antibodies: Examination of germinal center diversity by cloning and sequence analysis of genes encoding monoclonal antibodies elicited by a transition state analogue, Zhongde Wang

Dissertations from 1999

Calcium regulation in Tradescantia virginiana: Roles for involvement of inositol 1,4,5-trisphosphate and cyclic ADP-ribose, Anthony Lyndon DePass

Characterization of the yolk protein lipovitellin and its developmental fate in embryos and larvae of winter flounder, Pleuronectes americanus, Ruth C Hartling

Role of lipid signalling pathways in an intra and an extracellular phenomenon, Banafshe Larijani

Regulation of the actin cytoskeleton in the pollen tube, Luis Vidali

Androgen modulation of neurotrophic factor action: A possible mechanism for sexually dimorphic neural development, Jun Xu

Dissertations from 1998

Toward an antibody peptidase: Mechanistic studies of peptide-bond hydrolysis, Rebecca A. R Bryant

The role of mitochondria and proteasomes in T cell apoptosis, Lisa Marie Grimm

Modulation of epidermal growth factor receptor function by mutations within the actin-binding domain, Michael Ray Holbrook

The major function of eukaryotic small nucleolar RNAs is nucleotide modification in ribosomal RNA, Jingwei Ni

Alternative splicing of MDM2 during breast tumorigenesis and mammary gland development, Jan Pinkas

Box C/D small nucleolar RNAs: Biogenesis, structure and utilization for in vivo ribozyme studies, Dmitry A Samarsky

Understanding mitochondrial biogenesis through gene relocation, Marie Elise Sanchirico