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Dissertations from 2014

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Biophysical Studies of Axonal Transport, Leslie Cyle Conway

Dissertations from 2013

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Regulation and Action of Skp2 and Rhoa in Cell and Tumor Models: Investigation into the Molecular Mechanisms Responsible for the Aggressive Phenotype of Triplenegative Breast Cancer, Katrina D. Fagan-Solis

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The Unavoidable Threat of Aggregation: Implications for Folding and Function of a β-Rich Protein, Mylene Hazelle Anne Ferrolino

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The Role of YKL-40 in the Progression of Glioblastoma, Ralph Anthony Francescone

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Effects of Phytochemicals from Rhodiola crenulata on Highly Invasive Breast Cancer Cell Lines and Embryonic Models of Migration, Adaris Rodriguez-Cortes

Submissions from 2012

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Structure, function, and pharmacological chaperoning of human alpha-N-acetylgalactosaminidase, Nathaniel E Clark

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Molecular Interactions of the Tick Salivary Protein Salp15, Cassidy Dobson

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Identification and Functional Characterization of the Zebrafish Gene Quetschkommode (que), Timo Friedrich

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Individual polychlorinated biphenyl (PCB) congeners interact to disrupt thyroid hormone action during development, Stefanie Giera

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The viroporin activity of VP2, VP3 and VP4 contribute to the SV40 viral life cycle, Kristina M Giorda

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Target Recognition and Competitive Synaptogenesis in the Drosophila Giant Fiber System, Jason Joseph Hill

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Runx1 regulates c-Myc expression and the expansion of hematopoietic precursors in a C-terminally dependent manner, Paejonette Jacobs

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Structural studies of membrane-assembled PopD and PopB, the Pseudomonas aeruginosa type 3 secretion translocators, Fabian B Romano Chernac

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Molecular and Cellular Mechanisms of Dopamine Signaling in C. elegans, Khursheed Ahmad Wani

Dissertations from 2011

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The Role of Bacteriocins in Mediating Interactions of Bacterial Isolates from Cystic Fibrosis Patients, Emine Suphan Bakkal

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Mitochondrial DNA Polymerase IB: Functional Characterization of a Putative Drug Target for African Sleeping Sickness, David F. Bruhn

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The Role of the SUPRMAM1 Locus in Responses to Ionizing Radiation and Susceptibility to Mammary Tumors, Nicholas B. Griner

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Xenopus ADAM13 and ADAM19 are Important for Proper Convergence and Extension of the Notochord, Russell David Neuner

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Probing the regulation of vasculogenic mimicry in glioblastoma: Implications for treatment in patients, Stephen J. Scully

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Components of a Protein Machine: Allosteric Domain Assembly and a Disordered C-terminus Enable the Chaperone Functions of Hsp70, Robert G. Smock

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Regulation of mammary stem/progenitor cells by p53 and parity, Luwei Tao

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Functional tests of structural models for abortive cycling in T7 RNA polymerase, Ankit V Vahia

Submissions from 2010

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An integrative approach towards understanding the structure-function relationship of the epigenetic regulator methyl CpG binding protein 2, Rajarshi P Ghosh

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The Role of Runx1 N-Terminal Splice Isoforms in Hematopoietic Development, Emmett E. Hedblom

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Beyond cell Adhesion: Exploring the Role of Cadherin-11 Extracellular Processing by ADAM Metalloproteases in Cranial Neural Crest Migration, Catherine D. McCusker

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Notch 1 Mediated Inhibition of Nur77-induced apoptosis: Implications for T-cell Leukemia, Jonathan George Rud

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New Insights in the TSSK Family: Studies in the Activity and Function of the Testis Specific Serine Kinases, Julian Sosnik

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From Mouse Mammary Tumor Model to New Therapeutic Method ---Mammary Tumor Development in Balb/c-Trp53+/- Mice and Magnetic Nanoparticle Induced Heating for Cancer Treatment, Haoheng Yan

Submissions from 2009

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The Parkin-like ubiquitin E3 ligase Ariadne-1 in the mammalian brain: Potential implications for neurodegenerative disease, Juan G Cadena

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The active site chemistry of factor inhibiting HIF-1, coordination, bonding, and reaction, Yuan-Han Chen

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The role of EDEM1 in the quality control and degradation of misfolded glycoproteins, James H Cormier

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Delayed Anesthetic Preconditioning and Metallothioneins I+II: Novel Mediators of Anesthetic-Induced Protection, Scott David Edmands

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The Activity of eg5 and Dynein During Mammalian Mitosis, Nicholas P. Ferenz

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Toward an understanding of the role of the L1 stalk in translocation by the Escherichia coli ribosome, Mona Gupta

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The Conformational Gymnastics of the Escherichia Coli SecA Molecular Machine and its Interactions with Signal Sequences, Jenny Lynn Maki

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The role of the ER glucosyltransferase in the quality control of glycoprotein maturation, Bradley R Pearse

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The role of ERalpha, ERbeta and phytoestrogens from soy in p53-mediated response to DNA damage in mammary epithelium, Erick Roman Perez

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Retinoic acid transfer and protein-protein interaction between the cellular retinoic acid binding protein and the retinoic acid receptor probed by hydrogen deuterium exchange mass spectrometry, Virginie Sjoelund

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Determinants for Stop-Transfer and Post-Import Pathways for Protein Targeting to the Chloroplast Inner Envelope Membrane, Antonio Americo Barbosa Viana

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WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen, Fei Wang

Submissions from 2008

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Molecular mechanisms through which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interferes with estrogen regulation of PRL gene expression in vivo and in vitro, Jinyan Cao

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Regulation of RecA-dependent homologous recombination by 3'-5' exonucleases and the UvrD helicase in Escherichia coli K-12, Richard C Centore

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Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy, Ameya S Champhekar

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Functional analysis of Moe (Epb4.1l5) in zebrafish development and the identification of novel Epb4.1l5 binding proteins, Arne K Christensen

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The role of ovarian hormones in p53-mediated resistance to mammary tumorigenesis, Karen A Dunphy

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Drivers performance in response to sight-limited and multi-threat crash scenarios at mid-block crosswalks: An evaluation of advance yield markings and sign prompts, Lisandra Garay-Vega

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The roles of signal peptide peptidase -like proteases in Arabidopsis thaliana, Sungwon Han

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TRAF-interacting protein, an inhibitor of the canonical nuclear factor-kappaB pathway, plays a key role in the estradiol -dependent apoptosis of the dual-phenotype gamma amino butyric acid/glutamate neurons in the anteroventral periventricular nucleus of the male rat, Sudha Krishnan

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A post-import pathway for protein targeting to chloroplast inner membrane, Ming Li

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Hormones, growth factors, and the regulation of tumor suppressor pathways involved in parity -induced protection of breast cancer, Lesley Anne Mathews

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Novel developmental functions of the Drosophila SOX gene Dichaete, Krishna V Melnattur

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Organization and maintenance of the motor nerve terminal: Roles for presynaptic actin and perisynaptic Schwann cells, Stephanie Anne Moeckel Cole

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Organization and dynamics of actin and myosin during cytokinesis in mammalian epithelial cells, Kausalya Murthy

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The ubiquitin E3 ligase Human Homolog of Drosophila Ariadne-1 (HHARI) is a structural and functional homolog of Parkin and is required for myogenesis, Sangram S Parelkar

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Genetic studies of the regulation of RecA activity in Escherichia coli: A two filament model, Nicholas Renzette

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Environmental toxicants and white matter composition: Understanding the role of thyroid disruption, David S Sharlin

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The study of retinoic acids and Rhodiola as potential chemopreventional and chemotherapeutic reagents of breast cancer, Yifan Tu

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Characterization of bendless and interacting partners in Drosophila central synapse formation, Smitha Babu Uthaman

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The role of GTP regulation in chloroplast import, Fei Wang

Submissions from 2007

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Energy availability signals and the prohormone convertase 1 gene are regulated by Nhlh2, Dana L Fox

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Targeting bacteriolytic therapy of solid tumors with attenuated Salmonella typhimurium, Sabha Ganai

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The role of the crumbs complex in vertebrate rod morphogenesis and its regulation by a novel FERM protein mosaic eyes, Ya-Chu Hsu

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The role of inositol 1,4,5 -trisphosphate receptor type-1 in regulation of intracellular calcium oscillations in mouse eggs, Bora Lee

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Changes in the mutual orientation of tRNA and 23S rRNA at the peptidyl transferase center of the ribosome detected by crosslinking of a photoreactive transition-state analog, Anton V Manuilov

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Notch functions from the cytoplasm to the nucleus during T cell activation, Hyun Mu Shin

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Contribution of non-centrosomal microtubules to mitotic spindle assembly in mammalian cells, Ustun Serdar Tulu

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Modulation of Nhlh2 expression by energy availability leads to downstream effects on body weight regulation, Kristen R Vella

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Investigations of glycoprotein co-translational maturation in the cell, Ning Wang

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Genome-wide analysis for native thyroid hormone targets in developing brain and mechanisms of endocrine disruption at the thyroid hormone receptor, Seo-Hee You

Submissions from 2006

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Functional analysis of Hic-5/ARA55 isoforms in C2C12 myogenesis, Zhengliang Gao

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The effects of polychlorinated biphenyls on thyroid hormone-mediated action in vivo and in vitro, Kelly J Gauger

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Regulation of p53 by Mdm4 and ovarian hormones in mouse mammary glands, Shaolei Lu

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Postsynaptic mechanisms during synaptic plasticity at the Drosophila neuromuscular junction, Dennis Mathew

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The building of a centromeric nucleosome: Biochemical analysis and comparison of Cse4p, histone H3 and Cse4-286p to define the unique assembly pathway of a Cse4p nucleosome, Kelcy J Newell

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The influence of WC1 isoforms on gammadelta T cell function, Aric N Rogers

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The stability of T7 RNA polymerase elongation complexes and promoter function analysis by in vitro selection, Yi Zhou

Submissions from 2005

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The impact of PCBs on thyroid hormone directed brain development in rats, Eric A Iannacone

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Molecular and functional analysis of mutations that result in insecticide resistance in Colorado potato beetle, Hyo Jeong Kim

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The HFD of Cse4p is sufficient for a functional centromere specific nucleosome: An investigation into kinetochore formation on cen DNA, Lisa M Morey

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Microtubule dynamics and behavior during the assembly and disassembly of mammalian mitotic spindles, Nasser M Rusan

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Multiple roles for hedgehog signaling in zebrafish pituitary development, Jennifer L Sbrogna

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Cloning and functional characterization of the zebrafish mutation belladonna, Anandita Seth

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The action of T- and CS -syndrome pyrethroids on voltage-sensitive calcium channels in rat brain, Steven B Symington

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EGFR expression and activation in bovine cumulus cells and EGFR intramolecular regulation through interactions between tyrosines, Zhong Zhao

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Receptor clusters and dynamics in kinase regulation in bacterial chemotaxis, Li Zhi

Submissions from 2004

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Estrogen and progesterone regulate p53 activity in the mouse mammary epithelium through transforming growth factor beta dependent pathways, Klaus A Becker

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Notch-1 regulates IFN-gamma secretion through activation of NF-kappaB, Sridevi Gottipati

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NIH 3T3 fibroblast adhesion to a fibronectin substrate: The role of the arachidonic acid signaling pathway, Joffre Angelo Green

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Drosophila Wnt-1/Wingless undergoes a hydrophobic modification and is targeted to lipid rafts for secretion, a process that requires Porcupine, Xiaoling Hill

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The role of Notch in T cell activation and development, Amy Marie Laws

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Dietary phenolics for chemoprevention, Patrick P McCue

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Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction, Mary C Packard

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Understanding the allosteric mechanism of the Escherichia coli Hsp70 molecular chaperone, DnaK, Renuka Sivendran

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Using the mouse egg as a model system for the study of intracellular calcium signaling mechanisms, Jeremy T Smyth

Submissions from 2003

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Cyclooxygenase and cyclic AMP -dependent protein kinase regulate actin organization and cell motility, Honor L Glenn

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A new strategy for RNA structure probing in vivo: Targeting methylation small nucleolar RNPs to new sites in ribosomal RNA, Ben Liu

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Identification and characterization of cuticular collagens in the human filarial parasite Onchocerca volvulus, Wen Li

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Characterization and analysis of the cuticlin gene family of the human parasite Onchocerca volvulus, Michelle Renee Lizotte-Waniewski

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The role of N -linked glycans in protein quality control in the early secretory pathway, Sherri L Svedine

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When stress is good: Exercise and stress protein responses in mice and humans, Heather Sue Thompson