Publication Date
2009
Journal or Book Title
Biomacromolecules
Abstract
Here, we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and post-polymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).
DOI
https://doi.org/10.1021/bm801129y
Pages
353-359
Volume
10
Issue
2
Recommended Citation
Colak, Semra; Nelson, Christopher F.; Nüsslein, Klaus; and Tew, Gregory N., "Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity" (2009). Biomacromolecules. 991.
https://doi.org/10.1021/bm801129y