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Colloidal Particles as Antimicrobial Carrier Systems
Document Type: Open Access
Degree Program
Food Science
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2007
Month Degree Awarded
September
Primary Subject Category
Food science
Secondary Subject Category
Chemistry; Food science; Microbiology
Keywords
antimicrobial, Listeria, E. coli, delivery system
Advisor(s) or Committee Chair
Weiss, Jochen
Abstract
The objective of this thesis is to develop a method by which antimicrobials are delivered into a food product as a concentrated dose to the specific area in which the microorganism is growing without interference from the food matrix. More specifically, we plan to achieve this by delivering the antimicrobials nisin and lysozyme attached to nanoparticles and emulsion droplets. We hypothesize that (a) the attachment to a delivery vessel may increase the local concentration of the antimicrobial in the vicinity of the bacterial pathogens and (b) that the size and charge of the nanoparticle following attachment of the antimicrobials will be critical to its efficacy against pathogens. This thesis is designed to test this hypothesis using silver nanoparticles with well defined sizes and surface chemistry that allow control over the loading of the particle and oil droplets to which nisin is a secondary layer attached to pork gelatin which acts as the primary emulsifier.
Recommended Citation
Carnahan, Dustin W., "Colloidal Particles as Antimicrobial Carrier Systems" (2007). Masters Theses. Paper 40.
http://scholarworks.umass.edu/theses/40
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