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Access Type
Campus Access
Document Type
thesis
Degree Program
Electrical & Computer Engineering
Degree Type
Master of Science (M.S.)
Year Degree Awarded
2012
Month Degree Awarded
May
Keywords
3D fluorescence imaging, Contact imaging, lensless imaging
Abstract
Fluorescence microscopy has revolutionized medicine and biological science with its ability to study the behavior and chemical expressions of living cells. Fluorescent probes can label cell components or cells of a particular type. Clinically the impact of fluorescence imaging can be seen in the diagnosis of cancers, AIDS, and other blood related disorders.
Although fluorescence imaging devices have been established as a vital tool in medicine, the size, cost, and complexity of fluorescence microscopes limits their use to central laboratories. The work described in this thesis overcomes these limitations by developing a low cost integrated fluorescence microscope so single use fluorescence microscopy assays can be developed. These assays will enable at-home testing, diagnostics in resource limited settings, and improved emergency medicine.
DOI
https://doi.org/10.7275/2761520
First Advisor
Christopher Salthouse