Based on the travel blogs of 69 prefecture-level cities along the Yellow River basin, this study constructed a six-dimensional cultural perception system from the perspective of tourists, analyzed the similarities and differences in cultural perception across 6 dimensions between 69 prefecture-level cities using a deep learning textual thematic recognition method, and further proposed 10 cultural tourism regions with different cultural themes through the combination of a network-oriented geographic regionalization method and a text mining method. Lastly, the comparison of tourists’ cultural perceptions and emotional evaluations across 10 cultural tourism regions led to the conclusion that it is necessary to promote the Yellow River basin as an integrated and compound destination. This study contributed to the growing literature on cultural perception in travel and tourism research and proposed an approach to develop regional tourism for destination marketing organizations in the Yellow River basin.