Publication Date
2021
Journal or Book Title
Metabolites
Abstract
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6–7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (p = 0.003), and non-significantly with HDL-C (p = 0.06) and TL (p = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG (p = 0.04), LDL-C (p = 0.04), and TL (p = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data.
DOI
https://doi.org/10.3390/metabo11100657
Volume
11
Issue
10
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Boutot, Maegan E.; Whitcomb, Brian W.; Abdelouahab, Nadia; Baccarelli, Andrea A.; Boivin, Amélie; Caku, Artuela; Gillet, Virginie; Martinez, Guillaume; Pasquier, Jean-Charles; Zhu, Jiping; Takser, Larissa; St-Cyr, Lindsay; and Suvorov, Alexander, "In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels" (2021). Biostatistics and Epidemiology Faculty Publications Series.
11(10),
https://doi.org/10.3390/metabo11100657