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The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.
Fagherazzi, Guy/0000-0001-5033-5966; Laouali, Nasser/0000-0002-8532-456X; MacDonald, Conor/0000-0002-4989-803X
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Nutriperso Project (IDEX Paris Saclay); MGEN; Institut GUSTAVE ROUSSY; Ligue contre le CancerLigue nationale contre le cancer; National Research Agency under the program Investissement d'avenirFrench National Research Agency (ANR) [ANR-10-COHO-0006]; Ministere de l'enseignement superieur, de la recherche et de l'innovation [2102 918823]
Laouali, Nasser; MacDonald, Conor-James; Shah, Sanam; El Fatouhi, Douae; Mancini, Francesca Romana; Fagherazzi, Guy; and Boutron-Ruault, Marie-Christine, "Dietary Copper/Zinc Ratio and Type 2 Diabetes Risk in Women: The E3N Cohort Study" (2021). Biostatistics and Epidemiology Faculty Publications Series.