Publication Date
2021
Journal or Book Title
NPJ Breast Cancer
Abstract
Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among predominantly premenopausal women of the Nurses' Health Study II using conditional logistic regression (1057 cases, 1057 controls) and multivariable analyses evaluating all metabolites jointly. Eleven metabolites were associated with breast cancer risk (q-value < 0.2). Seven metabolites remained associated after adjustment for established risk factors (p-value < 0.05) and were selected by at least one multivariable modeling approach: higher levels of 2-aminohippuric acid, kynurenic acid, piperine (all three with q-value < 0.2), DMGV and phenylacetylglutamine were associated with lower breast cancer risk (e.g., piperine: ORadjusted (95%CI) = 0.84 (0.77-0.92)) while higher levels of creatine and C40:7 phosphatidylethanolamine (PE) plasmalogen were associated with increased breast cancer risk (e.g., C40:7 PE plasmalogen: ORadjusted (95%CI) = 1.11 (1.01-1.22)). Five amino acids and amino acid-related metabolites (2-aminohippuric acid, DMGV, kynurenic acid, phenylacetylglutamine, and piperine) were inversely associated, while one amino acid and a phospholipid (creatine and C40:7 PE plasmalogen) were positively associated with breast cancer risk among predominately premenopausal women, independent of established breast cancer risk factors.
ORCID
Zeleznik, Oana Alina/0000-0002-8705-1163; Clish, Clary/0000-0001-8259-9245; Tworoger, Shelley/0000-0002-6986-7046; Eliassen, A Heather/0000-0002-3961-6609
DOI
https://doi.org/10.1038/s41523-021-00262-4
Volume
7
Issue
1
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Funder
National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01 CA050385, UM1 CA186107, P01 CA087969, R01 CA49449, U01 CA176726, R01 CA67262]
Recommended Citation
Zeleznik, Oana A.; Balasubramanian, Raji; Zhao, Yibai; Frueh, Lisa; Jeanfavre, Sarah; Avila-Pacheco, Julian; Clish, Clary B.; Tworoger, Shelley S.; and Eliassen, A. Heather, "Circulating Amino Acids and Amino Acid-Related Metabolites and Risk of Breast Cancer Among Predominantly Premenopausal Women" (2021). Biostatistics and Epidemiology Faculty Publications Series.
7(1),
https://doi.org/10.1038/s41523-021-00262-4