Publication Date
2017
Journal or Book Title
Structural Dynamics
Abstract
Capturing protein structural dynamics in real-time has tremendous potential in elucidating biological functions and providing information for structure-based drug design. While time-resolved structure determination has long been considered inaccessible for a vast majority of protein targets, serial methods for crystallography have remarkable potential in facilitating such analyses. Here, we review the impact of microfluidic technologies on protein crystal growth and X-ray diffraction analysis. In particular, we focus on applications of microfluidics for use in serial crystallography experiments for the time-resolved determination of protein structural dynamics.
DOI
https://doi.org/http://dx.doi.org/10.1063/1.4979640
Volume
4
License
UMass Amherst Open Access Policy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Sui, Shuo and Perry, Sarah L., "Microfluidics: From Crystallization to Serial Time-Resolved Crystallography" (2017). Structural Dynamics. 840.
https://doi.org/http://dx.doi.org/10.1063/1.4979640