Publication Date
2016
Journal or Book Title
Drug Discovery Today
Abstract
Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancel cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
DOI
https://doi.org/10.1016/j.drudis.2016.05.011
Pages
1489-1494
Volume
21
Issue
9
License
UMass Amherst Open Access Policy
Recommended Citation
Yoshii, Tatsuyuki; Geng, Yingying; Peyton, Shelly; Mercurio, Arthur M.; and Rotello, Vincent M., "Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine" (2016). Drug Discovery Today. 896.
https://doi.org/10.1016/j.drudis.2016.05.011