Polymer Science and Engineering Department Faculty Publication Series
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Publication Synthesis and Solution Properties of Norbornene Based Polybetaines(2008-01-01) Colak, S; Tew, GNPublication Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids(2008-01-01) Yang, LH; Gordon, VD; Trinkle, DR; Schmidt, NW; Davis, MA; DeVries, C; Som, A; Cronan, JE; Tew, GN; Wong, GCLPublication De novo designed synthetic mimics of antimicrobial peptides(2008-01-01) Scott, RW; DeGrado, WF; Tew, GNPublication Fast Disinfecting Antimicrobial Surfaces(2009-01-01) Madkour, Ahmad E.; Dabkowski, Jeffrey M.; Nüsslein, Klaus; Tew, Gregory N.Silicon wafers and glass surfaces were functionalized with facially amphiphilic antimicrobial copolymers using the “grafting from” technique. Surface initiated atom transfer radical polymerization (ATRP) was used to grow poly(butylmethacrylate)-co-poly(Boc-aminoethyl methacrylate) from the surfaces. Upon Boc-deprotection, these surfaces became highly antimicrobial and killed S. aureus and E. coli 100% in less than 5 min. The molecular weight and grafting density of the polymer were controlled by varying the polymerization time and initiator surface density. Antimicrobial studies showed that the killing efficiency of these surfaces was independent of polymer layer thickness or grafting density within the range of surfaces studied.Publication Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity(2009-01-01) Colak, Semra; Nelson, Christopher F.; Nüsslein, Klaus; Tew, Gregory N.Here, we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and post-polymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).