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Publication Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids(2008-01-01) Yang, LH; Gordon, VD; Trinkle, DR; Schmidt, NW; Davis, MA; DeVries, C; Som, A; Cronan, JE; Tew, GN; Wong, GCLPublication Synthesis and Solution Properties of Norbornene Based Polybetaines(2008-01-01) Colak, S; Tew, GNPublication De novo designed synthetic mimics of antimicrobial peptides(2008-01-01) Scott, RW; DeGrado, WF; Tew, GNPublication Water-Soluble Polymers from Acid-Functionalized Norbornenes(2009-01-01) Lienkamp, K; Kins, CF; Alfred, SF; Madkour, AE; Tew, GNPublication Fast Disinfecting Antimicrobial Surfaces(2009-01-01) Madkour, Ahmad E.; Dabkowski, Jeffrey M.; Nüsslein, Klaus; Tew, Gregory N.Silicon wafers and glass surfaces were functionalized with facially amphiphilic antimicrobial copolymers using the “grafting from” technique. Surface initiated atom transfer radical polymerization (ATRP) was used to grow poly(butylmethacrylate)-co-poly(Boc-aminoethyl methacrylate) from the surfaces. Upon Boc-deprotection, these surfaces became highly antimicrobial and killed S. aureus and E. coli 100% in less than 5 min. The molecular weight and grafting density of the polymer were controlled by varying the polymerization time and initiator surface density. Antimicrobial studies showed that the killing efficiency of these surfaces was independent of polymer layer thickness or grafting density within the range of surfaces studied.Publication Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity(2009-01-01) Colak, Semra; Nelson, Christopher F.; Nüsslein, Klaus; Tew, Gregory N.Here, we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and post-polymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).Publication Biopolymerization-driven self-assembly of nanofiber air-bridges(2009-01-01) Pabba, S; Yazdanpanah, MM; Totten, BHF; Dobrokhotov, VV; Rathfon, JM; Tew, GN; Cohn, RWPublication Phosphonic Acid-Based Amphiphilic Diblock Copolymers Derived from ROMP(2009-01-01) Eren, T; Tew, GNPublication Acyclic Diene Metathesis (ADMET) polymerization of unsaturated thermotropic polyesters(2003-01-01) Qin, HH; Chakulski, BJ; Mather, PT; Constable, GS; Coughlin, EBPublication Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes(2009-01-01) Chen, JM; Hessler, JA; Putchakayala, K; Panama, BK; Khan, DP; Hong, S; Mullen, DG; DiMaggio, SC; Som, A; Tew, GN; Lopatin, AN; Baker, JR; Holl, MMB; Orr, BGPublication Fluorimetric Nerve Gas Sensing Based on Pyrene Imines Incorporated into Films and Sub-Micrometer Fibers(2009-01-01) Rathfon, JM; Al-Badri, ZM; Shunmugam, R; Berry, SM; Pabba, S; Keynton, RS; Cohn, RW; Tew, GNPublication Monovalent Salt Effects on the Membrane Activity of Antimicrobial Polymers(2009-01-01) Som, A; Choi, Y; Tew, GNPublication Divalent Metal Ion Triggered Activity of a Synthetic Antimicrobial in Cardiolipin Membranes(2009-01-01) Som, A; Yang, LH; Wong, GCL; Tew, GNPublication Dependence of Antimicrobial Selectivity and Potency on Oligomer Structure Investigated Using Substrate Supported Lipid Bilayers and Sum Frequency Generation Vibrational Spectroscopy(2009-01-01) Avery, CW; Som, A; Xu, YJ; Tew, GN; Chen, ZPublication Antimicrobial Polymers Prepared by Ring-Opening Metathesis Polymerization: Manipulating Antimicrobial Properties by Organic Counterion and Charge Density Variation(2009-01-01) Lienkamp, K; Madkour, AE; Kumar, KN; Nusslein, K; Tew, GNPublication "Doubly Selective" Antimicrobial Polymers: How Do They Differentiate between Bacteria?(2009-01-01) Lienkamp, Karen; Kumar, Kushi-Nidhi; Som, Abhigyan; Nüsslein, Klaus; Tew, Gregory N.Publication Telechelic and hemitelechelic POSS-polymer aggregates.(2003-01-01) Coughlin, EBPublication Phage Wrapping with Cationic Polymers Eliminates Nonspecific Binding between M13 Phage and High p/Target Proteins(2009-01-01) Lamboy, JA; Arter, JA; Knopp, KA; Der, D; Overstreet, CM; Palermo, EF; Urakami, H; Yu, TB; Tezgel, O; Tew, GN; Guan, ZB; Kuroda, K; Weiss, GAPublication POLY 540-Designing polymers with strong similarities to biology(2008-01-01) Tew, GPublication POLY 50-Capturing antimicrobial peptide activity in simpler molecules(2008-01-01) Tew, G