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Publication Effects of Fish Oil with Heat Treatment on Obesity, Inflammation, and Gut Microbiota in Ovariectomized Mice(2025) Kim, Judy; Fan, Rong; Kim, Young-Cheul; Chung, SoonkyuMenopause induces substantial metabolic changes, including a reduction in metabolic rate and an elevated risk of developing metabolic diseases. Fish oil (FO) supplementation has been shown to ameliorate menopause-associated metabolic risks. Hyperthermia treatment (HT) has recently gained attention for its potential to improve metabolic and immune health. However, it remains to be determined whether HT can confer metabolic benefits comparable to those of FO supplementation or enhance the metabolic benefits of FO supplementation. This study aims to delineate the distinctive and collaborative effects of HT and FO supplementation in mitigating menopause-associated metabolic dysfunction. Methods: Female C57BL/6 ovariectomized (OVX) mice were randomly assigned to four groups (n = 12/group) to evaluate the individual and combined effects of FO supplementation (5% w/w) and HT treatment. For HT, whole-body heat exposure was conducted at 40–41 °C for 30 min, 5 days per week. After 12 weeks, animals were used to evaluate the changes in glucose and lipid metabolism, obesity outcome, and inflammatory markers. The gut microbiome analysis was conducted from cecal content by 16S rRNA sequencing. Acute inflammation was induced by lipopolysaccharide (LPS) injection to evaluate inflammatory responses. Results: HT alone distinctively reduced weight gain, lowered core body temperature, and attenuated insulin resistance comparable to FO supplement in OVX mice. The collaborative effect of FO and HT was not evident in metabolic parameters but more prominent in attenuating proinflammatory responses and microbiota modulation. Conclusions: Our findings suggest that the combined treatment of FO supplementation and HT may serve as an effective strategy to mitigate menopause-associated immune susceptibility and metabolic dysfunction. These benefits are likely mediated, at least in part, through the reduction in inflammation and modulation of the gut microbiota.Publication Effects of Fish Oil with Heat Treatment on Obesity, Inflammation, and Gut Microbiota in Ovariectomized Mice(2025) Kim, Young-Cheul; Fan, Rong; Kim, Judy; Chung, SoonkyuMenopause induces substantial metabolic changes, including a reduction in metabolic rate and an elevated risk of developing metabolic diseases. Fish oil (FO) supplementation has been shown to ameliorate menopause-associated metabolic risks. Hyperthermia treatment (HT) has recently gained attention for its potential to improve metabolic and immune health. However, it remains to be determined whether HT can confer metabolic benefits comparable to those of FO supplementation or enhance the metabolic benefits of FO supplementation. This study aims to delineate the distinctive and collaborative effects of HT and FO supplementation in mitigating menopause-associated metabolic dysfunction. Methods: Female C57BL/6 ovariectomized (OVX) mice were randomly assigned to four groups (n = 12/group) to evaluate the individual and combined effects of FO supplementation (5% w/w) and HT treatment. For HT, whole-body heat exposure was conducted at 40–41 °C for 30 min, 5 days per week. After 12 weeks, animals were used to evaluate the changes in glucose and lipid metabolism, obesity outcome, and inflammatory markers. The gut microbiome analysis was conducted from cecal content by 16S rRNA sequencing. Acute inflammation was induced by lipopolysaccharide (LPS) injection to evaluate inflammatory responses. Results: HT alone distinctively reduced weight gain, lowered core body temperature, and attenuated insulin resistance comparable to FO supplement in OVX mice. The collaborative effect of FO and HT was not evident in metabolic parameters but more prominent in attenuating proinflammatory responses and microbiota modulation. Conclusions: Our findings suggest that the combined treatment of FO supplementation and HT may serve as an effective strategy to mitigate menopause-associated immune susceptibility and metabolic dysfunction. These benefits are likely mediated, at least in part, through the reduction in inflammation and modulation of the gut microbiota.Publication Knowledge, attitudes, and practices of registered dietitians and nutritionists regarding enteral and parenteral nutrition support in Ghana: a needs assessment study(2023) Ayande, Ruthfirst E. A.; Agordoh, Percival D.; Salino, Vanessa J.; Webster-Ariyan, Clarisa; Collier, Lindsay; Asante, Matilda; Carbone, Elena T.Background: There is a paucity of data on enteral and parenteral (EN and PN) nutrition support (NS) provided by nutrition and dietetic practitioners in adult acute care settings in Ghana. Furthermore, gray literature suggests that Ghanaian clinical nutrition professionals (CNPs) are seldom involved in advanced nutrition care teams. Objectives: To assess the knowledge, attitudes, and practices of Ghanaian CNPs regarding EN and PN. Methods: An online cross-sectional survey was administered to Ghanaian CNPs ahead of a professional development workshop on EN and PN Support. Participants were asked questions about initiation and timing of NS, and knowledge on availability of commercial formula. A 5-point Likert scale was used to assess self-efficacy in using EN and PN. To assess practical knowledge on EN and PN, participants were asked to identify whether EN or PN was indicated for seven short case scenarios. Open-ended questions were used to assess reasons for participant self-ratings. Results: A total of 76 dietitians, nutritionists, students, and interns completed the survey. For EN, self-efficacy scores were lowest for the calculation of enteral goal rate, and goal volume (mean 3.20 ± 1.27), and writing of EN prescriptions (mean 3.07 ± 1.29). Self-efficacy scores for the formulation of alternative formulas in lieu of commercial formula were the highest (3.63 ± 1.36). For PN, self-efficacy scores for all domains were lower than 3, with the lowest scores observed for writing PN prescriptions (2.19 ± 1.14) and determining micronutrient additives (2.12 ± 1.04). We identified limited training and lack of practical exposure to NS, limited ability to effectively monitor tube feeds, and prohibitive cost and limited availability of EN and PN formula among the barriers impacting self-efficacy scores. Conclusion: Given the vital role that CNPs play in the delivery of EN and PN, it is important to develop professional training programs especially focused on PN to bridge knowledge and practice gaps.Publication ALTERED VITAMIN-C TRANSPORT IN DIABETES-MELLITUS(1988) Cunningham, JJPublication PARENTERAL-NUTRITION FOR SEVERELY BURNED CHILDREN - ASSESSMENT OF THE AMA GUIDELINES FOR ZINC, COPPER AND MANGANESE(1988) CUNNINGHAM, J; LYDON, M; DECHEKE, MPublication BODY-SURFACE AREA AS A METABOLIC INDEX - CLINICAL AND PHYSIOLOGICAL PERSPECTIVES(1989) Cunningham, JJPublication Socio-Cultural Influences on Obesity and Inflammation among 2-Year Old Puerto-Rican Children at Risk for Asthma Development(2009-01) Kannan, S; Acosta, L; Acevedo-Garcia, D; Divjan, A; Bracero, L; Chew, GPublication ZINC AND COPPER STATUS OF SEVERELY BURNED CHILDREN DURING TPN(1991) Cunningham, JJ; LYDON, MK; BRIGGS, SE; DECHEKE, MPublication Publication REDUCED MONONUCLEAR LEUKOCYTE ASCORBIC-ACID CONTENT IN ADULTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS CONSUMING ADEQUATE DIETARY VITAMIN-C(1991) Cunningham, JJ; ELLIS, SL; MCVEIGH, KL; LEVINE, RE; CALLESESCANDON, JPublication PLASMA CERULOPLASMIN AND TOTAL COPPER LEVELS IN BURNED CHILDREN RECEIVING PARENTERAL COPPER - EFFECT OF DOSE AND BURN SEVERITY(1991) CUNNINGHAM, J; CHOWANSKI, Z; LEFFELL, M; STOKER, T; LYDON, M; HARMATZ, PPublication THE EFFECT OF DIETARY COPPER (CU) AND SEVERE THERMAL-INJURY ON MURINE SYSTEMIC AND MUCOSAL IMMUNE-RESPONSE(1992) CHOWANSKI, Z; HARMATZ, P; WEISSCARRINGTON, P; CARTER, E; DASCOLI, J; CUNNINGHAM, JPublication A food store intervention to reduce obesity in two American Indian communities: Impact on food choices and psychosocial indicators(2005-01) Gittelsohn, J; Anliker, JA; Ethelbah, B; Sharma, S; Curran, SB; Blake, K; Caballero, BPublication VITAMIN-C - AN ALDOSE REDUCTASE INHIBITOR THAT NORMALIZES ERYTHROCYTE SORBITOL IN INSULIN-DEPENDENT DIABETES-MELLITUS(1994) Cunningham, JJ; MEARKLE, PL; BROWN, RGPublication BURN SEVERITY, COPPER DOSE, AND PLASMA CERULOPLASMIN IN BURNED CHILDREN DURING TOTAL PARENTERAL-NUTRITION(1993) Cunningham, JJ; LEFFELL, M; HARMATZ, PPublication ROLE OF GROWTH-FACTOR RECEPTOR BLOCKADE IN THE INHIBITION OF INTESTINAL-CELL GROWTH BY INFANT FORMULAS(1994) PURTIC, B; EMERSON, R; SMITH, T; REENSTRA, W; CAPANO, G; HUGHES, A; CARRINGTON, PW; CUNNINGHAM, J; HARMATZ, PPublication NX6.25 - RECOGNIZING A BIVARIATE EXPRESSION FOR PROTEIN BALANCE IN HOSPITALIZED-PATIENTS(1994) Cunningham, JJPublication FAT MASS IN PREDICTING RESTING METABOLIC-RATE - REPLY(1992) Cunningham, JJ