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Multi-criteria optimization with dose -volume criteria

Tarek Halabi, University of Massachusetts Amherst


We construct a multi-criteria optimization program that automatically generates the multi-dimensional tradeoff curve of IMRT objectives. Linear convex approximations of non-convex IMRT objectives are used and the Pareto-optimality of approximations in nominal objective space is assessed. Tradeoff solutions are efficiently spread out on the tradeoff curve and an approach for navigating the multi-dimensional curve is shown. The combined effect of column and row generation in speeding up the linear programs is also examined. Our approach is applied to clinical cases and the results examined. An open-source package of our programs, LIRA, is provided.

Subject Area


Recommended Citation

Halabi, Tarek, "Multi-criteria optimization with dose -volume criteria" (2007). Doctoral Dissertations Available from Proquest. AAI3275757.