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Date of Award
9-2010
Access Type
Campus Access
Document type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
First Advisor
Vincent M. Rotello
Second Advisor
Robert M. Weis
Third Advisor
Jeanne A. Hardy
Subject Categories
Inorganic Chemistry | Organic Chemistry
Abstract
Gold nanoparticles (AuNPs) hold a great promise for biomedical applications. The inert inorganic core provides a scaffold to hold organic ligands and their payloads, while the diversity of monolayers provide a means to tailor AuNP surface properties for particular purposes. Based on our synthethic approach to ligand fabrication, our group has been able to control the chemical properties of AuNPs at the nanoscale level. These properties have made AuNPs an excellent scaffold for delivery applications. In this dissertation, it has been demonstrated how the properties of monolayers play a crucial role in achieving a desired biological goal. In each case, the monolayer of AuNPs has been tailored using organic synthesis as a strategy to afford stable and biocompatible biological tools. These engineered AuNPs demonstrate numerous biomedical applications, including a controlled release of payload, cellular uptake, gene regulations, cytosolic delivery, and cytotoxicity.
DOI
https://doi.org/10.7275/5675426
Recommended Citation
Chompoosor, Apiwat, "Gold Nanoparticles With Tailored Monolayers For Delivery Applications" (2010). Doctoral Dissertations 1896 - February 2014. 223.
https://doi.org/10.7275/5675426
https://scholarworks.umass.edu/dissertations_1/223