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Date of Award
9-2013
Access Type
Campus Access
Document type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
First Advisor
Matthew A. Holden
Second Advisor
Min Chen
Third Advisor
Richard W. Vachet
Subject Categories
Biophysics | Chemistry | Inorganic Chemistry
Abstract
Droplet-interface bilayers (DIBs) have been developed as a miniature model membrane system with distinct advantages over cell-based and other artificial membrane systems. This dissertation will describe a number of projects relating to DIB research, including: (i) the creation of new devices that allow the repeated addition and mixing of reagents to one side of a droplet-based membrane system; (ii) measurements of peptide and polymer mediated protein translocation across lipid bilayers; (iii) efforts to synthesize eukaryotic ion channels in DIBs; (iv) investigations on the asymmetric lipid dependence of the potassium channel KirBac1.1.
DOI
https://doi.org/10.7275/tnvt-2c95
Recommended Citation
Lein, Max J, "Droplet-Interface Bilayer Technologies for Membrane Protein Analysis and Molecular Trafficking Measurements" (2013). Doctoral Dissertations 1896 - February 2014. 546.
https://doi.org/10.7275/tnvt-2c95
https://scholarworks.umass.edu/dissertations_1/546