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Date of Award

9-2013

Document Type

Campus Access

Degree Name

Doctor of Philosophy (PhD)

Degree Program

Chemistry

First Advisor

Matthew A. Holden

Second Advisor

Min Chen

Third Advisor

Richard W. Vachet

Subject Categories

Biophysics | Chemistry | Inorganic Chemistry

Abstract

Droplet-interface bilayers (DIBs) have been developed as a miniature model membrane system with distinct advantages over cell-based and other artificial membrane systems. This dissertation will describe a number of projects relating to DIB research, including: (i) the creation of new devices that allow the repeated addition and mixing of reagents to one side of a droplet-based membrane system; (ii) measurements of peptide and polymer mediated protein translocation across lipid bilayers; (iii) efforts to synthesize eukaryotic ion channels in DIBs; (iv) investigations on the asymmetric lipid dependence of the potassium channel KirBac1.1.

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