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Author ORCID Identifier
N/A
AccessType
Open Access Dissertation
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Mechanical Engineering
Year Degree Awarded
2018
Month Degree Awarded
September
First Advisor
Blair J. Perot
Subject Categories
Computer-Aided Engineering and Design
Abstract
Protein folding studies require the development of micro-mixers that require less sample, mix at faster rates, and still provide a high signal to noise ratio. Chaotic to marginally turbulent micro-mixers are promising candidates for this application. In this study, various turbulence and unsteadiness generation concepts are explored that avoid cavitation. The mixing enhancements include flow turning regions, flow splitters, and vortex shedding. The relative effectiveness of these different approaches for rapid micro-mixing is discussed. Simulations found that flow turning regions provided the best mixing profile. Various turbulence models are simulated to determine appropriate model of the design requirements. Experimental validation of the optimal design is verified through laser confocal microscopy experiments
DOI
https://doi.org/10.7275/12327746
Recommended Citation
Inguva, Venkatesh, "Turbulent mixers for protein folding experiments" (2018). Doctoral Dissertations. 1444.
https://doi.org/10.7275/12327746
https://scholarworks.umass.edu/dissertations_2/1444