Transfusions are the most common procedure that hospitalized patients undergo. One of the risks associated with a transfusion is a transfusion related adverse event (TAAE). Transfusion associated adverse events can occur in any patient receiving a transfusion. Some patients are at risk of certain TAAEs (e.g., heart failure patients at risk of transfusion associated circulatory overload) while other events (e.g., allergic reactions) cannot always be anticipated. The severity of a TAAE can range from mildly uncomfortable to life threatening. Nurses need to be able to identify the signs and symptoms of a possible TAAE and intervene immediately by stopping the infusion of the blood product, taking immediate action to stabilize the patient and contacting the provider and transfusion medicine services/blood bank. This experimental study describes how the use of a transfusion checklist could facilitate the recognition and management of TAAEs for all clinicians and in particular, student nurses.