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Design, Synthesis and Self-assembly of Stimuli-responsive Amphiphiles for Antibacterial Applications
Author ORCID Identifier
https://orcid.org/0000-0001-6627-3317
AccessType
Campus-Only Access for Five (5) Years
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
Year Degree Awarded
2021
Month Degree Awarded
May
First Advisor
Sankaran Thayumanavan
Subject Categories
Chemistry | Microbiology
Abstract
Engineering of supramolecular assemblies at molecular level renders functional nanoparticles that exhibit specific response to certain environmental cues. Among responsive systems, enzyme-triggered materials are of particular interest due to their direct relevance in biological systems. Significant efforts have been made in developing enzyme-responsive materials that respond to biological enzymes. However, despite critical need, systems that respond to pathogenic bacteria or microbial enzymes with specific linkages to virulence or resistance mechanisms have been underexplored. Additionally, alternative use of supramolecular scaffolds that target pathogenic bacteria by artificial means including bacterial cell-wall engineering or shrink-wrapping the whole bacteria are less explored. To bridge this gap, this thesis focuses on understanding assembly-disassembly processes in amphiphilic systems, developing design and formulation strategies for smart materials that can respond to different bacterial cues.
DOI
https://doi.org/10.7275/22369029.0
Recommended Citation
Mohammed Koyasseril Yehiya, Thameez, "Design, Synthesis and Self-assembly of Stimuli-responsive Amphiphiles for Antibacterial Applications" (2021). Doctoral Dissertations. 2202.
https://doi.org/10.7275/22369029.0
https://scholarworks.umass.edu/dissertations_2/2202