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Author ORCID Identifier

https://orcid.org/0000-0001-6627-3317

AccessType

Campus-Only Access for Five (5) Years

Document Type

dissertation

Degree Name

Doctor of Philosophy (PhD)

Degree Program

Chemistry

Year Degree Awarded

2021

Month Degree Awarded

May

First Advisor

Sankaran Thayumanavan

Subject Categories

Chemistry | Microbiology

Abstract

Engineering of supramolecular assemblies at molecular level renders functional nanoparticles that exhibit specific response to certain environmental cues. Among responsive systems, enzyme-triggered materials are of particular interest due to their direct relevance in biological systems. Significant efforts have been made in developing enzyme-responsive materials that respond to biological enzymes. However, despite critical need, systems that respond to pathogenic bacteria or microbial enzymes with specific linkages to virulence or resistance mechanisms have been underexplored. Additionally, alternative use of supramolecular scaffolds that target pathogenic bacteria by artificial means including bacterial cell-wall engineering or shrink-wrapping the whole bacteria are less explored. To bridge this gap, this thesis focuses on understanding assembly-disassembly processes in amphiphilic systems, developing design and formulation strategies for smart materials that can respond to different bacterial cues.

DOI

https://doi.org/10.7275/22369029.0

Available for download on Saturday, May 14, 2022

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