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Author ORCID Identifier
https://orcid.org/0000-0001-8956-1581
AccessType
Campus-Only Access for Five (5) Years
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Chemistry
Year Degree Awarded
2021
Month Degree Awarded
September
First Advisor
S. Thayumanavan
Subject Categories
Materials Chemistry | Nanomedicine | Polymer Chemistry
Abstract
Cancer treatment by chemotherapeutics often results in off-target effects. To minimize the adverse effects of chemotherapy, multiple ways of achieving targeted drug delivery have evolved. Antibody-drug conjugates (ADCs) are one such class of drugs. However, development of new ADCs is challenging and not generalizable. In this dissertation, we utilize antibody-nanoparticle conjugates (ANCs) to address the limitations of ADCs as well as to develop a platform technology toward achieving targeted delivery of chemotherapeutics to cancer cells. In this dissertation, we have also set the groundwork for utilizing proteins/antibodies as drugs for cancer therapy. Two different nanoparticle systems were developed for (a) achieving targeted delivery of proteins to cancer cells selectively and (b) efficient intracellular delivery of large proteins such as antibodies. Extending the applicability of antibody-conjugated polymeric nanoparticle, anionic polymer-antibody conjugates were formulated for developing a technique to achieve targeted electroporation of biologics into cancer cells.
DOI
https://doi.org/10.7275/24358572
Recommended Citation
Singh, Khushboo, "Design and Formulation of Antibody-Conjugated Nanoparticles for Targeted Delivery of Drugs and Biologics" (2021). Doctoral Dissertations. 2357.
https://doi.org/10.7275/24358572
https://scholarworks.umass.edu/dissertations_2/2357
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.