Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password.
Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan.
Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires.
Author ORCID Identifier
Open Access Dissertation
Doctor of Philosophy (PhD)
Year Degree Awarded
Month Degree Awarded
Vincent M. Rotello
The surface chemistry of the nanomaterials creates an effective interface between two entirely different worlds: nanotechnology and biology. Understanding the interaction between nanomaterial surface chemistry and biological entities can be useful for a wide variety of biomedical applications as well as can provide crucial information for nanotoxicology. In my research, I have used gold nanoparticles as a model platform to synthesize a family of nanoparticles with atomic level control of their surface properties and probe their interaction with biological systems. First part of my research focused on the understanding the uptake mechanisms, toxicity, and hemolytic properties of cationic nanoparticles, an excellent gene delivery vectors, and provide design parameters to avoid toxic consequences. In the second part of my research, a new class of surface engineered antifouling nanomaterials were fabricated that can eschew plasma protein binding, providing opportunity to interrogate nano-biological behavior without any complications arising from the protein binding to nanomaterial surface. Since the surface chemistry of nanoparticles dictates the interaction between nanomaterials and biological entities, the findings in this thesis can be generalized to nanomaterials with a wide of variety of core materials of unique physical properties.
Saha, Krishnendu, "UNDERSTANDING STRUCTURE-PROPERTY RELATIONSHIPS AT THE NANO-BIO INTERFACE FOR DELIVERY APPLICATIONS" (2014). Doctoral Dissertations. 236.