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Author ORCID Identifier

https://orcid.org/0000-0002-1093-7097

AccessType

Campus-Only Access for Five (5) Years

Document Type

dissertation

Degree Name

Doctor of Philosophy (PhD)

Degree Program

Public Health

Year Degree Awarded

2021

Month Degree Awarded

September

First Advisor

Laura B Balzer

Second Advisor

David Benkeser

Third Advisor

Leontine Alkema

Subject Categories

Biostatistics

Abstract

In both individually randomized trials and cluster randomized trials, interventions often have differential effects depending on baseline characteristics, such as age or prevalence. Traditionally, effect modification has been examined with subgroup analyses or inclusion of cross-product terms in a parametric regression framework. In the first chapter, we develop a causal framework for evaluating effect modification in the context of sieve analyses in individually randomized vaccine trials. The second chapter, we present an R package for implementing targeted minimum loss-based estimation (TMLE) to assess effect heterogeneity with time-to-event data in the presence of competing risks and time-dependent confounding. In the third chapter, we focus on using TMLE to quantify effect modification in cluster randomized trials with few independent units.

DOI

https://doi.org/10.7275/23472542

Available for download on Thursday, September 01, 2022

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