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Author ORCID Identifier
Campus-Only Access for Five (5) Years
Doctor of Philosophy (PhD)
Year Degree Awarded
Month Degree Awarded
Edward J. Stanek III
Biostatistics | Public Health
Guidance is needed to choose the optimal algorithms to predict spoken word groups (Actions or Objects) from brain activation patterns using repeated fMRI (functional Magnetic Resonance Imaging) data.
A set of predictive classifier models for categorical outcomes were evaluated including logistic regression, Lasso, Ridge Regression, Elastic Net, and Support Vector Machine (SVM), Gaussian Process (GP), Gradient Boosting (GB), Gaussian Naive Bayes (GNB), K-nearest Neighbors (KNN), and Random Forest (RF). The evaluation was conducted on simulated high-dimensional fMRI scenarios. Comparisons were made based on predictive performance (Accuracy, AUC, Precision, Recall, F1 Score, Time). Through the study design and simulation, we identified patterns between the predictive model performance and key fMRI parameters including Signal-to-noise Ratio (SNR), Spatial Resolution, Temporal Correlation, Number of Regions of Interest (ROIs), and Spacing between Regions. By comparison of different simulation scenarios, better prediction was possible with higher SNR, Spatial Resolution and Temporal Correlation. The best-performing algorithms were chosen by the model performance metrics and consistency, and included SVM and Elastic Net, followed by Logistic Regression and Ridge. RF and GB performed the worst.
The best-performing classification algorithms from the simulation study were fitted to real-application fMRI data collected from healthy participants in a study of object and action picture naming in aphasia. The application evaluated the model performance and enabled the potential for clinically meaningful interpretation by identifying and visualizing multivariate voxel patterns.
Li, Minming, "STATISTICAL MACHINE LEARNING METHODS FOR MULTIVARIATE PATTERN ANALYSIS OF FMRI HIGH-DIMENSIONAL DATA" (2022). Doctoral Dissertations. 2651.
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Available for download on Friday, September 01, 2023