Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password.

Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan.

Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires.

Author ORCID Identifier

https://orcid.org/0000-0002-5415-2654

AccessType

Open Access Dissertation

Document Type

dissertation

Degree Name

Doctor of Philosophy (PhD)

Degree Program

Polymer Science and Engineering

Year Degree Awarded

2022

Month Degree Awarded

September

First Advisor

Murugappan Muthukumar

Subject Categories

Biochemical and Biomolecular Engineering | Bioelectrical and Neuroengineering | Biological Engineering | Biology and Biomimetic Materials | Biomaterials | Biomedical | Biotechnology | Chemical and Pharmacologic Phenomena | Complex Fluids | Complex Mixtures | Condensed Matter Physics | Digestive, Oral, and Skin Physiology | Dynamics and Dynamical Systems | Electrical and Electronics | Macromolecular Substances | Materials Chemistry | Medical Biotechnology | Medical Pharmacology | Medicinal-Pharmaceutical Chemistry | Nanomedicine | Nanotechnology Fabrication | Pharmaceutical Preparations | Pharmaceutics and Drug Design | Physical Chemistry | Physiological Processes | Polymer and Organic Materials | Polymer Chemistry | Polymer Science | Statistical, Nonlinear, and Soft Matter Physics | Systems and Integrative Physiology | Therapeutics | Thermodynamics

Abstract

The self-assembly of charged macromolecules forms the basis of all life on earth. From the synthesis and replication of nucleic acids, to the association of DNA to chromatin, to the targeting of RNA to various cellular compartments, to the astonishingly consistent folding of proteins, all life depends on the physics of the organization and dynamics of charged polymers. In this dissertation, I address several of the newest challenges in the assembly of these types of materials. First, I describe the exciting new physics of the complexation between polyzwitterions and polyelectrolytes. These materials open new questions and possibilities within the context of drug packaging and delivery, a selection of which are addressed in the second chapter. In the third chapter, fundamental questions about the chemical characteristics that influence the phase separation of polyzwitterions and polyelectrolytes are explored systematically. Finally, in the fourth chapter, the phenomenon of coacervation is harnessed in the electrochemical context, and several types of measurements of these properties are described in detail. This work represents the current state-of-the-art in the field of charged systems, and future work to create technologies (in the biomedical context, in particular) can all apply the fundamental results illuminated herein.

DOI

https://doi.org/10.7275/30763564

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Available for download on Friday, September 01, 2023

Share

COinS