Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password.

Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan.

Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires.

Author ORCID Identifier


Open Access Dissertation

Document Type


Degree Name

Doctor of Philosophy (PhD)

Degree Program


Year Degree Awarded


Month Degree Awarded


First Advisor

Vincent Rotello

Second Advisor

Michael Knapp

Third Advisor

Eric Strieter

Fourth Advisor

Ashish Kulkarni

Subject Categories



Bioorthogonal chemistry has emerged as a promising strategy for regulating bioprocesses through abiotic reactions. Bioorthogonal unmasking reactions mediated by transition metal catalysts (TMCs) present a powerful tool for biomedical applications due to their ability to generate therapeutic agents in situ, minimizing off-target effects. However, the direct application of TMC-mediated reactions in a biological environment poses challenges due to limited water solubility and biocompatibility of these catalysts. My Ph.D. research focused on encapsulating TMCs into polymer nanoparticles to obtain bioorthogonal nanocatalysts. These nanoscaffolds solubilize and stabilize hydrophobic catalyst molecules while preserving catalytic activity and stability in complex biological media. Furthermore, by varying their structure design and/or formulation strategies, these nanocatalysts provided enhanced biocompatibility while enabling controlled drug release for imaging and therapeutic applications.


Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Available for download on Sunday, September 01, 2024

Included in

Nanomedicine Commons