Off-campus UMass Amherst users: To download campus access dissertations, please use the following link to log into our proxy server with your UMass Amherst user name and password.
Non-UMass Amherst users: Please talk to your librarian about requesting this dissertation through interlibrary loan.
Dissertations that have an embargo placed on them will not be available to anyone until the embargo expires.
Open Access Dissertation
Doctor of Philosophy (PhD)
Year Degree Awarded
Amino Acids, Peptides, and Proteins | Biochemistry | Chemical Actions and Uses | Chemistry | Heterocyclic Compounds | Investigative Techniques | Laboratory and Basic Science Research | Macromolecular Substances | Materials Chemistry | Medicinal and Pharmaceutical Chemistry | Medicinal Chemistry and Pharmaceutics | Medicinal-Pharmaceutical Chemistry | Nanotechnology | Organic Chemicals | Organic Chemistry | Pharmaceutics and Drug Design | Polymer Chemistry
Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of encapsulated guest molecules, depending on the initial location of the ligand upon binding to a specific protein; (iii) decorate self-assembling and crosslinkable dendrons aiming to introduce a system incorporating multiple ligands, sequentially responsive to a reducing environment, and to specific proteins.
Amado Torres, Diego, "LIGAND-RECEPTOR INTERACTIONS FOR SUPRAMOLECULAR DISASSEMBLY WITH APPLICATIONS IN SCREENING AND DRUG DELIVERY" (2014). Doctoral Dissertations. 49.
Amino Acids, Peptides, and Proteins Commons, Biochemistry Commons, Chemical Actions and Uses Commons, Heterocyclic Compounds Commons, Investigative Techniques Commons, Laboratory and Basic Science Research Commons, Macromolecular Substances Commons, Materials Chemistry Commons, Medicinal and Pharmaceutical Chemistry Commons, Medicinal Chemistry and Pharmaceutics Commons, Medicinal-Pharmaceutical Chemistry Commons, Nanotechnology Commons, Organic Chemicals Commons, Organic Chemistry Commons, Pharmaceutics and Drug Design Commons, Polymer Chemistry Commons