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Author ORCID Identifier
N/A
AccessType
Open Access Dissertation
Document Type
dissertation
Degree Name
Doctor of Philosophy (PhD)
Degree Program
Public Health
Year Degree Awarded
2015
Month Degree Awarded
September
First Advisor
Alayne Ronnenberg
Second Advisor
Liz Bertone-Johnson
Third Advisor
Carol Bigelow
Fourth Advisor
Nancy Cohen
Subject Categories
Nutrition
Abstract
Abnormal menstrual cycle length, pattern and bleed duration are associated with reduced fecundity and increased risk of miscarriage. The menstrual cycle is governed by the hypothalamus-pituitary-ovarian (HPO) axis, and nutritional factors may affect menstrual characteristics by influencing the HPO axis. Identifying these factors may lead to cost effective ways to improve reproductive outcomes. In a cross-sectional analysis of 164 18- to 30-year-old women, we examined the association of adiposity, dietary fat intake and vitamin D status with menstrual cycle characteristics. Adiposity was measured using dual-energy X-ray absorptiometry (DXA); dietary intake was assessed using a food frequency questionnaire, and fasting venous samples were collected for measurement of vitamin D. Most study participants were Caucasians (83%). Approximately 20% of women were overweight (BMI 25-29.9 kg/m2); 6% were obese (BMI ≥ 30 kg/m2). However, when using DXA measurements, 45% of women had a percent total body fat (%TBF) > 32, indicating obesity. The odds of having an irregular cycle pattern were three times higher among women with < 32% TBF compared to those with more adiposity [OR=3.1 95% CI (0.9 to 10.2) p=0.07]. When considering body fat distribution, the odds of an irregular cycle were 2.8 times higher in women with ≤ 41% gynoid fat [OR=2.8 95% CI(0.9, 8.6) p=0.07]; a one standard deviation increase in G/A (gynoid/android) fat mass was associated with a 50% decreased odds of an irregular cycle pattern [OR=0.45 95% CI (0.21, 1.1) p=0.07]. Among dietary factors, higher intake of n-6 PUFA was associated with irregular cycles (β= 0.16, p=0.05) and both short (β= 0.23, p 50nmol/L) was 80% lower among women with irregular cycles compared to those with regular cycles (OR= 0.19; 95% CI: 0.04, 0.92). Our findings suggest that dietary factors are associated with menstrual cycle characteristics, particularly cycle regularity. If our findings are confirmed in larger prospective studies, they suggest that dietary manipulation may be one approach to improving menstrual cycle function.
DOI
https://doi.org/10.7275/7533813.0
Recommended Citation
Natarajan, Radhika, "Association of Dietary Factors with Menstrual Cycle Characteristics" (2015). Doctoral Dissertations. 534.
https://doi.org/10.7275/7533813.0
https://scholarworks.umass.edu/dissertations_2/534