The Maturing of Hormesis as a Credible Dose-Response Model
Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced by its absence from major toxicological/risk assessment texts, governmental regulatory dose-response modeling for risk assessment, and non-visibility in major professional toxicological society national meetings. This paper traces the historical evolution of the hormetic dose-response hypothesis, why this model is not only credible but also more common than the widely accepted threshold model in direct comparative evaluation, and how the toxicological community made a critical error in rejecting hormesis, a rejection sustained over 70 years.
Calabrese, Edward J.
"The Maturing of Hormesis as a Credible Dose-Response Model,"
Dose-Response: An International Journal: Vol. 1:
3, Article 3.
Available at: https://scholarworks.umass.edu/dose_response/vol1/iss3/3