Hormesis is a common phenomenon in a number of biomedical areas. However, the basic nature of this phenomenon remains largely unknown. Therefore, significant uncertainty is inevitable in attempts to apply hormesis as a pro-health and anti-aging tool. Evidence supporting that hormetic-like effects may be the result of a generalized wholeorganism adaptive epigenetic response is reviewed. Specific hormesis-inducing interventions during development would allow to achieve an optimal balance between activation and repression of various genes and thus to prevent age-related degenerative diseases and slow aging. The reasons that oscillating temperature mild stress could potentially be used for human application are discussed.
Vaiserman, Alexander M
"HORMESIS, ADAPTIVE EPIGENETIC REORGANIZATION, AND IMPLICATIONS FOR HUMAN HEALTH AND LONGEVITY,"
Dose-Response: An International Journal: Vol. 8:
1, Article 6.
Available at: https://scholarworks.umass.edu/dose_response/vol8/iss1/6