•  
  •  
 

Authors

Yingtai Chen, School of Clinical Medicine of Lanzhou University, People’s Republic of China; Yale University School of Medicine, USA; Department of General Surgery of the Second Hospital of Lanzhou University, People’s Republic of China
Xuezhong Chen, Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic of China
Yumin Li, Department of General Surgery of the Second Hospital of Lanzhou University, People’s Republic of China
Hong Zhang, Department of Radiology, Institute of Modern Physics, The Chinese Academy of Science, People’s Republic of China
Yi Xie, Department of Radiology, Institute of Modern Physics, The Chinese Academy of Science, People’s Republic of China
Xiaowei Zhang, Central Laboratory of the First Hospital of Lanzhou University, People’s Republic of China
Huizi Ren, Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic of China
Yanling Wang, Department of Radiology, Institute of Modern Physics, the Chinese Academy of Science, People’s Republic of China
Shiqi Liao, Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic of China
Mingyan He, Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic of China
Jinyu Ren, The Liver Center of University of Kansas Medical Center (KUMC), Kansas City, MO USA
Jieyu Zhang, Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic of China
Xiadong Zhou, Tumor Hospital of Institute of Medical Science of Gansu Province, People’s Republic of China
Tongzhang Zheng, Yale University School of Medicine, USA
Briseis A Kilfoy, Yale University School of Medicine, USA
Yawei Zhang, Yale University School of Medicine, USA

Abstract

The aim of this study was to examine the early effects of low dose 12C6+ irradiation or X-ray on peripheral blood lymphocytes (PBL) of patients with alimentary tract cancer and to explore mechanisms that may be involved in an antitumor immune response. We found that the percentage of T lymphocyte subsets, the mRNA expression levels of IL-2 and IFN- γ in PBL, and their protein levels in supernatant were significantly increased 24 hours after exposure to low dose radiation. The effects were more pronounced in the group receiving 0.05Gy 12C6+ ion irradiation than the group receiving X-ray irradiation. There was no significant change in the percentage of NK cell subsets and TNF-α production of PBL. Our study suggests that low dose irradiation could alleviate immune suppression caused by tumor burden and that the effect was more pronounced for 0.05Gy high linear energy transfer (LET) 12C6+ irradiation.

Download

Share

COinS