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Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin.
Dietary Curcumin and Human Health)
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Scuto, Maria Concetta; Mancuso, Cesare; Tomasello, Barbara; Ontario, Maria Laura; Cavallaro, Andrea; Frasca, Francesco; Maiolino, Luigi; Salinaro, Angela Trovato; Calabrese, Edward J.; and Calabrese, Vittorio, "Curcumin, Hormesis and the Nervous System" (2019). Nutrients. 28.