Visconti, Pablo
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Email Address
Birth Date
Job Title
Professor, Department of Veterinary and Animal Sciences, College of Natural Sciences
Last Name
Visconti
First Name
Pablo
Discipline
Animal Sciences
Expertise
Signal Transduction Pathways During Sperm Capacitation
Introduction
My long term goal is to understand how the sperm acquire fertilizing capacity at the molecular level. In particular, I am focusing in several basic questions that arise from the capacitation model in the figure such as:
1. Which are the protein substrates for tyrosine phosphorylation and how are they involved in the capacitation process?
2. Which are the tyrosine kinase/s and/or phosphotyrosine phosphatases responsible for the increase in protein tyrosine phosphorylation observed during capacitation?
3. How capacitation and the capacitation-associated hyperpolarization are regulated by components of the capacitation medium?
4. How are changes in cAMP, protein tyrosine phosphorylation and hyperpolarization of the sperm plasma membrane integrated to regulate capacitation?
5. Where in the sperm do the changes in cAMP, protein tyrosine phosphorylation and hyperpolarization occur during capacitation?
6. How cholesterol removal affects signaling pathways during sperm capacitation?
1. Which are the protein substrates for tyrosine phosphorylation and how are they involved in the capacitation process?
2. Which are the tyrosine kinase/s and/or phosphotyrosine phosphatases responsible for the increase in protein tyrosine phosphorylation observed during capacitation?
3. How capacitation and the capacitation-associated hyperpolarization are regulated by components of the capacitation medium?
4. How are changes in cAMP, protein tyrosine phosphorylation and hyperpolarization of the sperm plasma membrane integrated to regulate capacitation?
5. Where in the sperm do the changes in cAMP, protein tyrosine phosphorylation and hyperpolarization occur during capacitation?
6. How cholesterol removal affects signaling pathways during sperm capacitation?