The growing interest in cold-formed steel (CFS) structures has drawn researchers’ attention to the seismic performance of CFS shear walls in seismically active regions. Cementitious panels used as sheathing in CFS shear walls and diaphragms offer superior strength and energy dissipation capacity. These sheathing panels are becoming increasingly ubiquitous in light-framed structures due to their fire-resistance properties. This project consists of two phases. In phase 1, the study investigates key parameters, namely edge distance, stud thickness, and fastener type, affecting the cyclic response of 108 fiber-cement board (FCB)-sheathed-CFS shear wall connections. Additional factors, such as overdriven screws and the presence of tongues on panel edges, are also evaluated. The study examines hysteretic performance, failure modes, and fastener tilting. In the second phase of this work, 24 specimens tested under FEMA 461 loading protocol are selected, and 24 identical specimens are assembled and tested under CUREE loading protocol. These experimental tests aim to evaluate and compare the cyclic response of FCB-sheathed CFS connections subjected to the FEMA-461 and CUREE loading protocols. These experimental specimens are designed to represent a segment of a shear wall, consisting of two CFS studs fastened on both sides with FCB using eight screws. A total of 108 specimens with varying edge distances, stud thicknesses, and screw types are tested under the FEMA 461 cyclic loading protocol, providing a large suite of experimental data for these connection types. Additionally, the hysteretic performance and failure mode of 24 FEMA-tested and 24 CUREE-tested specimens are compared. Population-level analysis is conducted to quantify variability in screws-fastened connections and to explore relationships among experimental variables, failure modes and screw titling. The results aim to inform national design specifications and contribute to a comprehensive database on the hysteretic behavior of FCB-sheathed-CFS shear wall connections, enabling more reliable design of shear walls and diaphragms sheathed with fiber-cement boards.