Firms innovate to prevent the presence of microbial pathogens in foods and to address other safety problems. To date, studies on the economics of food safety innovation are relatively rare. We designed a series of case studies of such innovation in the meat industry. Our objectives were to identify and analyze different types of innovation, the drivers of innovation, the mode of innovation development, and the impact of innovation on food safety and firm performance. Here we present the survey instrument developed to conduct the case studies. This instrument can be applied, with minor modifications to reflect research objectives, to a wide variety of innovations and adaptations of innovations in the food industry.