Macau’s gaming boom and the planned construction of the Hong Kong, Macau, and Zhuhai (HMZ) Bridge present good opportunities for the three destinations to develop tourism. However, developing tourism without regional coordination and collaboration could result in overcapacity and cut-throat competition among HMZ and dampen the healthy growth of tourism in the region. This study investigates the HMZ tourism cooperation issue by conducting in-depth interviews with government officials, industry practitioners and tourism researchers in HMZ. The question it seeks to answer is: How should the three destinations join hands to develop the region’s tourism in a cooperative way? Based on the interviews, strengths, weaknesses, opportunities, and threats (SWOT) analyses were conducted with a focus on HMZ’s internal relationship and threats from external competitors in tourism development. Policy recommendations that could benefit HMZ as an integrated region were made based on the analyses.