Tourism destinations are complex units: they include a multitude of suppliers with individual goals but interrelated with the creation of a tourism product. This triggers interesting effects on actors’ interactions, recently theorized as coopetitive. However, knowledge has grown in a fragmented manner: contributions differ for the level of analysis and the strategic and operational components addressed. Moreover, the dynamics stemming from the heterogeneous and complementary nature of the tourism product remain largely unexplored. To expand this growing research domain, this study first proposes a systematic literature review to synthesize and critically analyze existing tourism and hospitality literature. Second, it identifies the primary dimensions of coopetition including them in a theoretical framework of the antecedents, processes, and outcomes of coopetition. This study contributes to science with a deeper understanding of coopetition in destinations, and to practice with a support tool for decision-making processes aimed at increasing tourism firms’ performance and resilience.